Prevalence of anti‐egg albumin antibodies in cerebrospinal fluid of patients with mild and severe Alzheimer’s Disease. Correlation with gender and incidence of anti‐casein antibodies and AGEs.

Background Alzheimer’s Disease (A.D.) is a multifactorial process. Advanced glycation end products (AGEs) have been correlated with disease development1. Additionally, high concentrations of antibodies against the food derived antigens egg-albumin and bovine casein, detected in patients preliminary research presented by our team, previously (AAIC 2018). In present study, casein as well AGEs were cerebrospinal fluid 36 mild 35 severe 13 healthy individuals correlation between measured parameters sample properties was attempted. Method ELISA plates pre-treated highly hydrophilic microlon resin used for purpose this study2. Egg-albumin or attached at measurement antibodies. polyclonal multiple AGE to detect CSF AGEs. Result According results, 48,6% samples AD had anti-egg albumin concentration higher than mean idividuals+2SD (characterized positive) compared 8.3% positive disease. An overall 265% increase observed patients, indicating association severity. The difference significant p = 0.01 according mann witney U test. Lower female either (Figure 1). Much lower incidence anti-casein antibody found (5.7% versus 0% AD). A slight, not statisticaly significant, (23.7%) (16.2%) also most samples. Conclusion results indicated potential severity increased male patients. case References: 1. Takeuchi et al., Current Pharmaceutical Design, 14(10), 2008, 973-978. 2. P. Eleftheriou, etal. Biomed. Res. Int., 2014.